A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson’s disease
Identifieur interne : 001F63 ( Main/Exploration ); précédent : 001F62; suivant : 001F64A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson’s disease
Auteurs : Rejko Krüger [Allemagne] ; Manu Sharma [Allemagne] ; Olaf Riess [Allemagne] ; Thomas Gasser [Allemagne] ; Christine Van Broeckhoven [Belgique] ; Jessie Theuns [Belgique] ; Jan Aasly [Norvège] ; Grazia Annesi [Italie] ; Anna Rita Bentivoglio [Italie] ; Alexis Brice [France] ; Ana Djarmati [Allemagne] ; Alexis Elbaz [France] ; Matthew Farrer [États-Unis] ; Carlo Ferrarese [Italie] ; J. Mark Gibson [Irlande (pays)] ; Georgios M. Hadjigeorgiou [Grèce] ; Nobutaka Hattori [Japon] ; John P. A. Ioannidis [Grèce] ; Barbara Jasinska-Myga [Pologne] ; Christine Klein [Allemagne] ; Jean-Charles Lambert [France] ; Suzanne Lesage [France] ; Juei-Jueng Lin [Taïwan] ; Timothy Lynch [Irlande (pays)] ; George D. Mellick [Australie] ; Francesa De Nigris [Italie] ; Grzegorz Opala [Pologne] ; Alessandro Prigione [Italie] ; Aldo Quattrone [Italie] ; Owen A. Ross [États-Unis] ; Wataru Satake ; Peter A. Silburn [Australie] ; Eng King Tan [Singapour] ; Tatsushi Toda [Japon] ; Hiroyuki Tomiyama [Japon, Grèce] ; Karin Wirdefeldt [Suède] ; Zbigniew Wszolek [États-Unis] ; Georgia Xiromerisiou [Grèce] ; Demetrius M. Maraganore [États-Unis]Source :
- Neurobiology of aging [ 0197-4580 ] ; 2009.
Abstract
High-profile studies have provided conflicting results regarding the involvement of the
GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the
The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five
This largest association study performed to define the role of any gene in the pathogenesis of Parkinson’s disease revealed no overall strong association of
Url:
DOI: 10.1016/j.neurobiolaging.2009.11.021
PubMed: 20036034
PubMed Central: 4724437
Affiliations:
- Allemagne, Australie, Belgique, France, Grèce, Irlande (pays), Italie, Japon, Norvège, Pologne, Singapour, Suède, Taïwan, États-Unis
- Latium, Minnesota, Province d'Anvers, Région flamande, Svealand, Île-de-France
- Anvers, Paris, Rome, Stockholm, Tokyo
- Université d'Anvers
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000631
- to stream Pmc, to step Curation: 000628
- to stream Pmc, to step Checkpoint: 000830
- to stream Ncbi, to step Merge: 000B00
- to stream Ncbi, to step Curation: 000B00
- to stream Ncbi, to step Checkpoint: 000B00
- to stream Main, to step Merge: 002120
- to stream Main, to step Curation: 001F63
Le document en format XML
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Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation wicri:level="4"><nlm:aff id="A3">Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurology, University of Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, University of Trondheim</wicri:regionArea><wicri:noRegion>University of Trondheim</wicri:noRegion></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Cnrs, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name><affiliation wicri:level="1"><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A12">INSERM, Unit 708, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 708, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A13">UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Mayo Clinic, Jacksonville</wicri:regionArea><wicri:noRegion>Jacksonville</wicri:noRegion></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><nlm:aff id="A32">INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex</wicri:regionArea><wicri:noRegion>Lille cedex</wicri:noRegion><wicri:noRegion>Lille cedex</wicri:noRegion></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="3"><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Cnrs, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lin, Juei Jueng" sort="Lin, Juei Jueng" uniqKey="Lin J" first="Juei-Jueng" last="Lin">Juei-Jueng Lin</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Neurology, Chushang Show-Chwan Hospital, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Neurology, Chushang Show-Chwan Hospital</wicri:regionArea><wicri:noRegion>Chushang Show-Chwan Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital</wicri:regionArea><wicri:noRegion>Royal Brisbane Hospital</wicri:noRegion></affiliation></author><author><name sortKey="De Nigris, Francesa" sort="De Nigris, Francesa" uniqKey="De Nigris F" first="Francesa" last="De Nigris">Francesa De Nigris</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Prigione, Alessandro" sort="Prigione, Alessandro" uniqKey="Prigione A" first="Alessandro" last="Prigione">Alessandro Prigione</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><nlm:aff id="A26">Institute of Neurology, University Magna Graecia, Catanzaro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Mayo Clinic, Jacksonville</wicri:regionArea><wicri:noRegion>Jacksonville</wicri:noRegion></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital</wicri:regionArea><wicri:noRegion>Royal Brisbane Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng King" last="Tan">Eng King Tan</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>National Neuroscience Institute and Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew" sort="Wszolek, Zbigniew" uniqKey="Wszolek Z" first="Zbigniew" last="Wszolek">Zbigniew Wszolek</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Neurology, Mayo Clinic Jacksonville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Jacksonville</wicri:regionArea><wicri:noRegion>Mayo Clinic Jacksonville</wicri:noRegion></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><nlm:aff id="A31">Department of Neurology, Mayo Clinic, Rochester, MN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20036034</idno><idno type="pmc">4724437</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724437</idno><idno type="RBID">PMC:4724437</idno><idno type="doi">10.1016/j.neurobiolaging.2009.11.021</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000631</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000631</idno><idno type="wicri:Area/Pmc/Curation">000628</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000628</idno><idno type="wicri:Area/Pmc/Checkpoint">000830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000830</idno><idno type="wicri:Area/Ncbi/Merge">000B00</idno><idno type="wicri:Area/Ncbi/Curation">000B00</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B00</idno><idno type="wicri:doubleKey">0197-4580:2009:Kruger R:a:large:scale</idno><idno type="wicri:Area/Main/Merge">002120</idno><idno type="wicri:Area/Main/Curation">001F63</idno><idno type="wicri:Area/Main/Exploration">001F63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A large-scale genetic association study to evaluate the contribution of <italic>Omi/HtrA2</italic> (PARK13) to Parkinson’s disease</title><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Riess, Olaf" sort="Riess, Olaf" uniqKey="Riess O" first="Olaf" last="Riess">Olaf Riess</name><affiliation wicri:level="1"><nlm:aff id="A2">Medical Genetics, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Genetics, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation wicri:level="4"><nlm:aff id="A3">Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation wicri:level="4"><nlm:aff id="A3">Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurology, University of Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, University of Trondheim</wicri:regionArea><wicri:noRegion>University of Trondheim</wicri:noRegion></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Cnrs, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name><affiliation wicri:level="1"><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A12">INSERM, Unit 708, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Unit 708, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A13">UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Mayo Clinic, Jacksonville</wicri:regionArea><wicri:noRegion>Jacksonville</wicri:noRegion></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><nlm:aff id="A32">INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex</wicri:regionArea><wicri:noRegion>Lille cedex</wicri:noRegion><wicri:noRegion>Lille cedex</wicri:noRegion></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="3"><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Cnrs, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lin, Juei Jueng" sort="Lin, Juei Jueng" uniqKey="Lin J" first="Juei-Jueng" last="Lin">Juei-Jueng Lin</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Neurology, Chushang Show-Chwan Hospital, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Neurology, Chushang Show-Chwan Hospital</wicri:regionArea><wicri:noRegion>Chushang Show-Chwan Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital</wicri:regionArea><wicri:noRegion>Royal Brisbane Hospital</wicri:noRegion></affiliation></author><author><name sortKey="De Nigris, Francesa" sort="De Nigris, Francesa" uniqKey="De Nigris F" first="Francesa" last="De Nigris">Francesa De Nigris</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Prigione, Alessandro" sort="Prigione, Alessandro" uniqKey="Prigione A" first="Alessandro" last="Prigione">Alessandro Prigione</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><nlm:aff id="A26">Institute of Neurology, University Magna Graecia, Catanzaro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Mayo Clinic, Jacksonville</wicri:regionArea><wicri:noRegion>Jacksonville</wicri:noRegion></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital</wicri:regionArea><wicri:noRegion>Royal Brisbane Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng King" last="Tan">Eng King Tan</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>National Neuroscience Institute and Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew" sort="Wszolek, Zbigniew" uniqKey="Wszolek Z" first="Zbigniew" last="Wszolek">Zbigniew Wszolek</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Neurology, Mayo Clinic Jacksonville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Jacksonville</wicri:regionArea><wicri:noRegion>Mayo Clinic Jacksonville</wicri:noRegion></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><nlm:aff id="A31">Department of Neurology, Mayo Clinic, Rochester, MN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="ISSN">0197-4580</idno><idno type="eISSN">1558-1497</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">High-profile studies have provided conflicting results regarding the involvement of the <italic>Omi/HtrA2</italic> gene in Parkinson’s disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common <italic>Omi/HtrA2</italic> variants in the Genetic Epidemiology of Parkinson’s disease (GEO-PD) consortium.</p><p id="P2">GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the <italic>Omi/HtrA2</italic> gene in approximately 2–3 kb intervals (rs10779958, rs2231250, rs72470544, rs1183739, rs2241028). Fixed as well as random effect models were used to provide summary risk estimates of <italic>Omi/HtrA2</italic> variants.</p><p id="P3">The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five <italic>Omi/HtrA2</italic> SNPs and PD were observed using either fixed effect or random effect models. The summary odds ratios ranged between 0.98 and 1.08 and the estimates of between-study heterogeneity were not large (non-significant <italic>Q</italic> statistics for all 5 SNPs; <italic>I</italic><sup>2</sup> estimates 0–28%). Trends for association were seen for participants of Scandinavian descent for rs2241028 (OR 1.41, <italic>p</italic> = 0.04) and for rs1183739 for age at examination (cut-off 65 years; OR 1.17, <italic>p</italic> = 0.02), but these would not be significant after adjusting for multiple comparisons and their Bayes factors were only modest.</p><p id="P4">This largest association study performed to define the role of any gene in the pathogenesis of Parkinson’s disease revealed no overall strong association of <italic>Omi/HtrA2</italic> variants with PD in populations worldwide.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Grèce</li><li>Irlande (pays)</li><li>Italie</li><li>Japon</li><li>Norvège</li><li>Pologne</li><li>Singapour</li><li>Suède</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Latium</li><li>Minnesota</li><li>Province d'Anvers</li><li>Région flamande</li><li>Svealand</li><li>Île-de-France</li></region><settlement><li>Anvers</li><li>Paris</li><li>Rome</li><li>Stockholm</li><li>Tokyo</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><noCountry><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name></noRegion><name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><name sortKey="Riess, Olaf" sort="Riess, Olaf" uniqKey="Riess O" first="Olaf" last="Riess">Olaf Riess</name><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name></region><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name></country><country name="Norvège"><noRegion><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name></noRegion><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="De Nigris, Francesa" sort="De Nigris, Francesa" uniqKey="De Nigris F" first="Francesa" last="De Nigris">Francesa De Nigris</name><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><name sortKey="Prigione, Alessandro" sort="Prigione, Alessandro" uniqKey="Prigione A" first="Alessandro" last="Prigione">Alessandro Prigione</name><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></country><country name="France"><region name="Île-de-France"><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></region><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name></country><country name="États-Unis"><noRegion><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name></noRegion><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><name sortKey="Wszolek, Zbigniew" sort="Wszolek, Zbigniew" uniqKey="Wszolek Z" first="Zbigniew" last="Wszolek">Zbigniew Wszolek</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name></noRegion><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name></country><country name="Grèce"><noRegion><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name></noRegion><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name></country><country name="Japon"><noRegion><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name></noRegion><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name></country><country name="Pologne"><noRegion><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name></noRegion><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name></country><country name="Taïwan"><noRegion><name sortKey="Lin, Juei Jueng" sort="Lin, Juei Jueng" uniqKey="Lin J" first="Juei-Jueng" last="Lin">Juei-Jueng Lin</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name></noRegion><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name></country><country name="Singapour"><noRegion><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng King" last="Tan">Eng King Tan</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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